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High blood pressure causes. Fainting in Healthy People May Be First Sign of Heart Trouble

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Image caption, A blood clot in a vessel supplying the brain can starve the brain of oxygen Researchers have identified a gene that may put people at greater risk of strokes and heart attacks. Writing in PLOS ONE they say high blood pressure causes gene fault may encourage the formation of blood clots - the ultimate cause of most heart attacks and strokes.

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Scientists hope gene tests may help doctors one day to pinpoint individuals more likely to suffer these conditions. But experts say lifestyle factors such as smoking and exercise have the greatest influence on risk.

For those who have ever suddenly and briefly lost consciousness, it's a disconcerting situation that typically triggers a thorough medical workup. Unfortunately, it's often tough for physicians to determine just what caused a first fainting episode. A large new Danish study provides a nationwide picture of how one-time fainters fare over several years.

Around one in 10 people in the Caucasian population carries this variation of the gene, named PIA2. And researchers from King's College London reviewed more than 80 studies involving about 50, people - the largest analysis of this genetic fault to date.

Threat to unders They found individuals with PIA2 were more likely to have a stroke - caused by a blood clot blocking blood supply to the brain - than those without the gene.

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But how significant this increase is depends on an individual's baseline risk - influenced by factors such as smoking, diet, weight and exercise, the scientists say. In a second study published in the same journal, the scientists show PIA2 is also linked to an increased risk of heart attacks in people under high blood pressure causes More research is needed to see whether this holds true for the whole population, they say.

Aboutpeople have a stroke in the UK each year and more thanheart attacks are recorded annually. Both thrombotic strokes the most common kind and heart attacks are caused by blockage of blood vessels in the heart and brain - ultimately through the formation of clots.

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Platelets help trigger the formation of clots to stop bleeding after injury. But scientists say carrying the gene may render them overactive. They caution that overall the genes play a smaller role in risk than more established factors, such as high blood pressure and obesity.

Gene linked to higher stroke and heart attack risk

But developing a genetic test could help predict people at highest risk, allowing doctors to suggest more potent kezelése szivattyú cukorbetegség or lifestyle changes, they say.

Prof Albert Ferro, of King's College London, who led the research, told the BBC: "We would now need to validate this test and see how useful it is in the clinical world. Regular exercise, eating a balanced diet and stopping smoking can be important steps to significantly reduce your stroke risk.

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