Hypertension in diabetes mellitus in: Orvosi Hetilap Volume Issue 39 ()

Antidiabetic drugs in hypertension. New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

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H Pécs, Hungary. Patients and Methods: Forty-seven hypertensive patients antidiabetic drugs in hypertension underwent transcutaneous CO2 therapy were enrolled.

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Thirty healthy individuals were recruited for the control group. Blood samples were taken one hour before, as well as one hour, 24 hours and 3 weeks after the first CO2 treatment.

antidiabetic drugs in hypertension

Controls did not undergo CO2 treatment. ACE inhibition seems to enhance the effect of CO2 treatment. CO2 passes freely through membranes and has a well-known vasodilation effect. Both in vitro and in vivo studies have demonstrated a rightward shift of the oxygen-hemoglobin O2-Hb dissociation curve after administration of CO2.

These effects have been confirmed by Minamiyama and Yamamoto by using intra-vital microscopy video images to demonstrate subcutaneus vasodilation after CO2 administration 3.

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In addition, CO2 has been shown to increase blood flow rate in the observed subcutaneus vessels 3. Taking advantage of its easy use, low cost and high efficiency, CO2 treatment is used to cure several diseases notably, peripheral arterial and venous disorders e.

antidiabetic drugs in hypertension

The pathophysiological link between these conditions is the presence of excessive oxidative stress. Investigating the relation between oxidative stress and CO2, Veselá and Wilhelm found CO2 to play a protective role in scavenging free radicals and suppressing oxidative metabolism 6. Increased plasma ADMA concentrations were shown in patients with classic cardiovascular risk factors e. Its kezelés cukorbetegség vélemények predictive value in cardiovascular risk assessment, already demonstrated by several authors, has been confirmed by a recent systematic review involving nearly 20, individuals.

Understanding diabetes and hypertension symptoms, risk factors and treatment

Willeit et al. Furthermore, strong correlations were found between ADMA levels and intima-media thickness and ADMA levels and aortic augmentation index, which are early markers of endothelial dysfunction 11 It also inhibits NO formation and induces vascular free radical production leading to increased oxidative stress Accordingly, ADMA is a useful tool for studying the NO system especially in conditions with inflammation and oxidative stress ADMA is produced intracellularly, as a result of methylated protein degradation, and metabolized mainly by dimethylarginine dimethylaminohydrolase enzyme DDAH.

Expression and function of Javítás cukorbetegség kezelésének is impaired by several conditions, e. Furthermore, loss of efficiency of DDAH is directly proportional to the severity of oxidative stress In antidiabetic drugs in hypertension, ADMA is considered as a marker and mediator of oxidative stress and an indicator of vascular well-being. Patients and Methods Study design.

1. Introduction

Patients who had previously received CO2 therapy were excluded. Moreover, patients who had suffered from myocardial infarction, stroke or undergone open surgery less than a year before the study were also excluded.

antidiabetic drugs in hypertension

Additionally, individuals diagnosed with cancer or kidney injury were also excluded. To monitor the changes of plasma ADMA concentrations, blood samples were obtained one hour before and 1 hour, 24 hours and 3 weeks after the first CO2 treatment, respectively. The patients received three transcutaneous CO2 treatments per week for 3 weeks.

A vérnyomás-emelkedés hátterében az esetek egy részében nephropathia diabetica áll, amely mind 1-es, mind 2-es típusú diabetesben kialakulhat, de a két diabetestípusban észlelhető renalis szövődmény néhány klinikai jellegzetességben eltér egymástól. A 2-es típusú cukorbetegségben és kórmegelőző állapotaiban észlelt hypertoniaesetek döntő hányadának kialakulását a metabolikus szindróma koncepciója alapján értelmezzük. A kezelés megválasztása a cardiovascularis kockázat becslésén nyugszik, a terápiában — étrendi és életmódbeli tanácsok mellett — általában csak kombinált antihipertenzív kezeléssel érhetünk el eredményt.

CO2 gas was administered for 35 minutes in a plastic bag sealed at mid-thoracic level, as previously described by Fabry et al. Clinical data medical history, age, weight, height, drugs, ejection fraction, laboratory data, etc. Healthy individuals were recruited for the control group.

antidiabetic drugs in hypertension

Only one sample was obtained from controls. Informed written consent was obtained from every patient. Sampling and measurement of ADMA. After centrifugation 1, × g, 10 min plasma was collected and stored at —70˚C until analysis.

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The measuring range of the assay was 0. Statistical analysis. Differences during the follow-up were investigated by paired-sample t-test.

Patients and Methods

All p-values less than 0. Results We enrolled 47 patients and 30 controls. Clinical characteristics of the subjects are shown in Table I. Baseline plasma ADMA concentrations were significantly higher in the patients compared to the controls 0.

Patients suffering from diabetes mellitus had significantly higher baseline plasma ADMA concentrations compared to non-diabetic patients 0.

antidiabetic drugs in hypertension

Twenty-four hours after the treatment, ADMA levels increased approximately to the baseline. Comparing ADMA concentrations measured 1 and 24 hours after the first CO2 treatment, a modest but statistically not significant increase was observed.

antidiabetic drugs in hypertension